Developmental Pathway of Specialized T Cells Defined

Researchers have cracked how a particular type of immune cell develops in the body and protects against infection and disease. And the discovery could help in the development of more preventive treatments, according to a new study.

The research, led by Murdoch Children’s Research Institute and Federation University Australia, has uncovered how these specialized white blood cells operate and can produce an immune response. 

Associate Professor Dan Pellicci said by understanding the function of these cells, they could be harnessed to help prevent cancer and highly infectious diseases such as COVID-19, Strep A and tuberculosis.

Published in Science Immunology, the study involved samples donated to the Melbourne Children’s Heart Tissue Bank from heart surgery patients up to 16 years old. From these samples, the researchers looked at the role of gamma delta T cells within the thymus gland, a small organ located within the chest, close to the heart.

Associate Professor Pellicci said the study showed for the first time how this organ produced these infection-fighting immune cells.

“We have large numbers of these specialised cells in our blood and tissues, which accumulate as we become adults. Until our study, it was unclear how these cells develop in the body,” he said.

“We have shown how these cells are trained over three stages, similar to receiving a primary, secondary and tertiary education, and fully formulate within the thymus. Following this education, the cells are ready to enter the rest of the body and are completely capable of fighting infections.”

Associate Professor Pellicci said previous studies suggested that these immune cells were mainly derived in the liver during a baby’s development in the womb, but this research debunked that theory.

“Many experts assumed that after birth, the thymus played little role in the development of these cells as we age, but we now know this little unsung organ helps the body prepare for a lifetime of good health,” he said.

“The more we know about these cells the greater the likelihood of unlocking new ways to treat infectious diseases and cancer.”

Reference: Perriman L, Tavakolinia N, Jalali S, et al. A three-stage developmental pathway for human Vγ9Vδ2 T cells within the postnatal thymus. Sci Immunol. 2023;8(85):eabo4365. doi: 10.1126/sciimmunol.abo4365

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