Egg and Sperm Cell Size Evolved From Competition

In most living animals, egg cells are vastly larger than sperm cells. In humans, for example, a single egg is 10 million times the volume of a sperm cell.

In a new study, Northwestern University researchers found that competition and natural selection drove this curious size discrepancy.

Using mathematical modeling, the researchers considered a time very early in evolution when primordial species reproduced using external fertilization. In the model, bigger reproductive cells, or gametes, presented a competitive edge because they could hold more nutrients for a potential zygote. Smaller gametes, however, required fewer resources to make, which put less stress on the parent.

"Organisms either needed to produce the biggest gametes with the most provisions or the smallest gametes to use the least resources," said Northwestern's Daniel Abrams, the study's senior author. "We believe this size difference is almost inevitable, based on plausible assumptions about how sexual reproduction works and how natural selection works."

Abrams is a professor of engineering sciences and applied mathematics at Northwestern's McCormick School of Engineering. Joseph Johnson, a Ph.D. candidate in Abrams' laboratory, is the paper's first author. Nathan White and Alain Kangabire, undergraduate students in Abrams' lab, coauthored the paper.

The Northwestern team's model begins with isogamy, a primordial state in which all gametes were roughly the same size and distinct sexes did not yet exist. The team then developed and applied a simple mathematical model to show how isogamy transitioned to anisogamy, a state where the gametes either became very small or quite large -- precursors to sperm and eggs associated with biological sexes today.

In the model, anisogamy emerged from competition to survive in an environment with limited resources. Gametes were more likely to survive if they had an edge in size over their neighbors, leading to an "arms race" favoring larger and larger gametes. But organisms could not produce many sex cells without needing more and more resources themselves. They could, however, save their resources by producing a lot of tiny gametes.

"Early in evolution when sexual reproduction emerged, gametes were symmetrical. But this is where that symmetry breaks," Abrams said. "We end up with some organisms specializing in large gametes and others specializing in small gametes."

Abrams said one remaining mystery is why some isogamist species still exist today. Some types of algae and fungi, for example, reproduce either asexually or with symmetrical mating types.

"There have been different theories about how anisogamy emerged, going all the way back to Charles Darwin," Abrams said. "Issues in evolutionary biology are very hard to test because we can only study species that are around today. We can't see what they looked like billions of years ago. Using mathematical models can yield new insight and understanding."

Reference: Johnson JD, White NL, Kangabire A, Abrams DM. A dynamical model for the origin of anisogamy. J Theor Biol. 2021;521:110669. doi:10.1016/j.jtbi.2021.110669

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