Fibrocell/UCLA Study on Human Skin Cells Yields Promising Results
News Mar 21, 2013
The study has been accepted for publication in the Stem Cell Research and Therapy peer-reviewed journal and the provisional paper is available online. It was conducted under the guidance of James Byrne, PhD, assistant professor, UCLA Department of Molecular and Medical Pharmacology, at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research.
“We continue to be pleased with the results of our collaboration with UCLA to pursue the full potential of fibroblasts,” said David Pernock, CEO and Board Chair, Fibrocell Science.
The cells may be used by academic researchers and pharmaceutical companies to evaluate new drug compounds for safety and to develop patient-specific therapies for multiple disease states, including heart disease, Parkinson’s disease and diabetes. Using skin cells is more advantageous to the patient than obtaining cells from bone marrow or adipose tissue (fat). A skin biopsy is quicker to perform, less painful and minimally invasive.
Dr. Byrne’s study found human skin cells cultured in the presence of a chemical known as BAY11 resulted in reproducible increased expression of the OCT4 gene that did not inhibit normal cell growth. OCT4 is involved in many cell processes, but is primarily known to maintain pluripotency and regulate cell differentiation. It is typically used as a marker to identify undifferentiated cells.
The development of a more stable method to create iPS cells from skin cells allows for the potential of a reproducible commercial manufacturing process. The study was performed at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research and Department of Molecular and Medical Pharmacology at UCLA in conjunction with the Department of Cell Biology and Neuroscience at Rutgers University.
Cell Technology Used to Treat Osteochondral Knee DefectNews
Autologous cells of stromal vascular fraction were transplanted to a 36-year-old man with the use of fibrin matrix.READ MORE
Gene Editing Technology May Improve Accuracy of Predicting Heart Disease RiskNews
Scientists may now be able to predict whether carrying a specific genetic variant increases a person’s risk for disease using gene editing and stem cell technologies.READ MORE