Immune System Surprise Hints at New Strategy for Fighting HIV
News Nov 18, 2014
The discovery of the innate immunity system’s role in mobilizing the body’s defenses against invading microorganisms has been long studied at Yale. Now in the Nov. 17 issue of the journal Nature Immunology, Yale researchers led by Margarita Dominguez-Villar and David Hafler have discovered a surprising twist to the story that may open a new avenue in the fight against HIV.
An immune system response to microbial invaders is triggered when a family of receptors found in immune cells called Toll-like receptors are activated by invaders.
To the surprise of the Yale team, the researchers found that when a Toll-like receptor inside the CD4 immune cells, which are regularly destroyed by HIV, are blocked, it actually depresses — not activates — an immune system reaction.
Researchers now want to investigate whether manipulating this receptor could combat HIV infection.
Macrophage's Role in Maintaining Tattoos Could Hold Key to RemovalNews
Researchers have discovered that, though a tattoo may be forever, the skin cells that carry the tattoo pigment are not. Instead, the cells can pass on the pigment to new cells when they die. The study suggests ways to improve the ability of laser surgery to remove unwanted tattoos.READ MORE
New Causes of Cellular Decline in Prematurely Aging Kids DiscoveredNews
In a recent paper published in Cell Reports, Saint Louis University researchers have uncovered new answers about why cells rapidly age in children with a rare and fatal disease. The data points to cellular replication stress and a mistaken innate immune response as culprits, and the team found success in the laboratory in blocking these processes with vitamin D.READ MORE
Measuring Neutrophil Motility Could Lead to Accurate Sepsis DiagnosisNews
Mass. General researchers design device that rapidly diagnoses sepsis with more than 95 percent accuracy.READ MORE
Comments | 0 ADD COMMENT
6th Annual Congress on Biology and Medicine of Molecules
Sep 17 - Sep 18, 2018