Inexpensive Technique Developed to Manufacture Nanofibers
News May 22, 2015
Scientists at the University of Georgia say they have developed an inexpensive way to manufacture nanofibers, which are polymers made from natural materials like proteins or from human-made substances to make plastic, rubber, or fiber, including biodegradable materials.
The new method, dubbed "magnetospinning," provides a simple, scalable, and safe means for producing large quantities of nanofibers that can be embedded with a multitude of materials, including live cells and drugs, according to the researchers.
Thousands of times thinner than the average human hair, nanofibers are used by medical researchers to create advanced wound dressings and for tissue regeneration, drug testing, stem cell therapies, and the delivery of drugs directly to the site of infection.
"The process we have developed makes it possible for almost anyone to manufacture high-quality nanofibers without the need for expensive equipment," said Sergiy Minko, Ph.D., study co-author and the Georgia Power Professor of Polymers, Fibers and Textiles in UGA's college of family and consumer sciences. "This not only reduces costs, but it also makes it possible for more businesses and researchers to experiment with nanofibers without worrying too much about their budget."
Currently, the most common nanofiber manufacturing technique, called electrospinning, uses high-voltage electricity and specially designed equipment to produce the polymer strings. Equipment operators must have extensive training to use the equipment safely.
"In contrast to other nanofiber spinning devices, most of the equipment used in our device is simple," said Dr. Minko. "Essentially, all you need is a magnet, a syringe, and a small motor."
At laboratory scale, a v simple handcrafted setup is capable of producing spools containing hundreds of yards of nanofibers in a matter of seconds. Polymer that has been melted or liquefied in a solution is mixed with biocompatible iron oxide or another magnetic material and placed inside a hypodermic needle. This needle is then positioned near a magnet that is fixed atop a spinning circular platter. As the magnet passes by the tip of the needle, a droplet of the polymer fluid stretches out and attaches to the magnet, forming a nanofiber string that winds around the platter as it continues to spin.
The device can spin at more than 1,000 revolutions per minute, enough time to create more than 50 kilometers (or about 31 miles) of ultra-thin nanofiber.
It's a relatively simple process, but it produces a high-quality product, said Alexander Tokarev, Ph.D., a postdoctoral research in Dr. Minko’s lab and co-author of the study (Magnetospinning of Nano- and Microfibers) which appears in Advanced Materials.
“The product we can make is just as thin and just as strong as nanofibers created through other methods," he said. "Plus, users don't have to worry about the safety issues of using high voltages or the complexity of other machines."
The researchers can use this method to create a variety of nanofibers simply by changing the polymer placed in the syringe. They can, for example, create specially designed nanofibers that will promote the growth of stem cells. Fibers like these are currently used to create scaffolding for lab-grown tissues and organs.
Nanofibers can also be loaded with proteins, nanotubes, fluorescent materials and therapeutic agents.
"We can use almost any kind of polymer with this platform, and we can tailor make the nanofibers for different applications," explained Dr. Minko. "It's like cooking. We just change the ingredients a bit, and the kind of fiber we get is very different."
Nanoparticles show great promise as diagnostic tools and drug delivery agents. But until now, most nanoparticles had to be injected into the bloodstream because they weren’t absorbed well orally. Now, researchers have modified nanoparticles to improve their uptake in the gastrointestinal tract.