JDRF Partners with Plureon to Explore Generating Insulin-Producing Cells from Adult Stem Cells
News Feb 08, 2008
The Juvenile Diabetes Research Foundation (JDRF) has announced that it is partnering with Plureon Corporation, a biotechnology company based in Winston-Salem, N.C. that focuses on developing therapeutic applications of stem cells.
Through its Industry Discovery and Development Partnership Program, JDRF is providing $500,000 over two years of research funding aimed at developing an insulin-producing beta cell therapy product for the treatment of type 1 diabetes.
“Plureon is exploring exciting alternatives to treat or cure diabetes by developing cell therapies to replace beta cells using adult stem cells as a source,” said Julia Greenstein, Therapeutic Program Director for Replacement at JDRF. “The results from this study may provide a new strategy to restore function of insulin-producing cells, creating a significant, positive clinical impact on patients with diabetes.”
“This award enables us to extend our research in the field of diabetes,” said Hal Eason, founder and CEO of Plureon. “By leveraging our existing technology and know-how across additional sources of stem cells, we hope to open new pathways towards a cure. We are grateful for JDRF’s partnership in this pursuit.”
The project plans to use Plureon’s technology platform to isolate adult stem cells from a type 1 diabetes patient and re-program them to generate fully functional pancreatic beta-cells.
The objective is to return the re-programmed insulin-producing cells back into the patient in an autologous manner, i.e., without the need for immunosuppressive agents normally required for organ transplantation – in this manner, the patient’s own transplanted cells will be capable of glucose-dependent insulin secretion and the restoration of normal blood sugar levels.
Plureon is the latest company to work with JDRF through its innovative Industry Discovery and Development Partnership program. Through the program, JDRF partners with pharmaceutical, biotech, and medical device businesses that seek to develop drugs, treatments, technologies, and other therapeutics leading to a cure, reversal, or prevention of type 1 diabetes and its complications. To date, JDRF has 22 IDDP partners across a range of research areas, committing approximately $25 million in research funding.
Scientists at the University of Bristol have invented a new technology that could lead to the development of a new generation of smart surgical glues and dressings for chronic wounds. The new method involves re-engineering the membranes of stem cells to effectively “weld” the cells together.READ MORE
Zebrafish, in contrast to humans, have outstanding regenerative capacities: and can regrow brain cells from so-called progenitor cells. Scientists have now determined that these progenitor cells consist of eight different sub-populations. In a fish model of Alzheimer’s disease, only some of these populations increased proliferation to restore lost cells.READ MORE