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Cell Line Engineering Makes Well-characterized Antibody More Accessible

News   Aug 01, 2018 | Original story sourced from the US National Institute of Standards and Technology

New Cell Lines Produce an Antibody Key for Biologic Drug Production

HeLa cancer cells appear green wherever mouse monoclonal antibodies (mAb) have bound to tubulin, a structural protein important in cell division. Binding to tubulin and preventing cell growth is one way that mAb drugs could kill tumors -- the type of research that may benefit from the use of NIST's monoclonal antibody reference material, NISTmAb. Credit: ©EnCor Biotechnology Inc.



Alzheimer's Trafficking Defect Corrected in Rodents


UT Southwestern researchers have succeeded in neutralizing what they believe is a primary factor in late-onset Alzheimer’s disease, opening the door to development of a drug that could be administered before age 40, and taken for life, to potentially prevent the disease in 50 to 80 percent of at-risk adults.


Immune System Kept in Check by Protein Police


Researchers learn how a key transcription factor helps regulate the immune system and could be critical to understanding autoimmune disease and cancer immunosuppression.


How Anti-psychotic Medications Drive Weight Gain


About three million Americans take antipsychotic medications for conditions such as bipolar disorder, PTSD and schizophrenia. These medications are vital for mental health, yet many people stop taking them because of the side effects of weight gain and associated metabolic diseases.



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