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Novel Mechanism That Enhances Hematopoietic Stem Cell Formation Discovered

News   Nov 17, 2020 | Original story from Max-Planck-Gesellschaft

 
Novel Mechanism That Enhances Hematopoietic Stem Cell Formation Discovered

Repetitive elements induce a RIG-I-like receptor-mediated inflammation that regulates the emergence of hematopoietic stem and progenitor cells. Lefkopoulos et al. report that repetitive element (RE) RNA present during developmental hematopoiesis activates the RIG-I-like receptor pathway to provide the inflammatory signals necessary for HSPC formation. The RE RNA is depicted as cables that fuel the 'DJ controller' with electricity. RIG-I and MDA5 function as decks for the controller to play music, which represents the inflammatory signals turning into blood cells, whereas LGP2 functions as a mixer by controlling the levels of inflammation RIG-I and MDA5 provide. Nature is all-inclusive, like a rainbow. Credit: llustration concept by M. Derecka, Marika ki and ET. Cover art by @kostispavlou.

 
 
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