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Novel Mechanism Underlying Hair Thinning Identified

News   Mar 17, 2021 | Original story from Tokyo Medical and Dental University

 
Novel Mechanism Underlying Hair Thinning Identified

Young HFSCs undergo symmetric cell divisions (SCDs) and asymmetric cell divisions (ACDs) to generate new bulge cells for their self-renewal and expansion. Whereas aged HFSCs provoke hemidesmosomal instability including COL17A1 and undergo stress response (SR) type ACDs to induce epidermal differentiation that triggers their delamination, thereby causing stepwise miniaturization of HFs and hair thinning and loss. Credit: Department of Stem Cell Biology/ TMDU

 
 
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