Researchers Design Programmable DNA Hydrogels for Advanced Cell Culture
There is an urgent need for new approaches to create soft and biocompatible materials with predictable properties.
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In-vitro culture of biological cells plays an important role in advancing biological research. However, currently available cell culture materials have significant drawbacks. Many of them are derived from animal sources, leading to poor reproducibility, and making it difficult to fine-tune their mechanical properties. Therefore, there is an urgent need for new approaches to create soft and biocompatible materials with predictable properties.
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Subscribe for FREEThe programmable properties of the material point to promising potential for new applications in tissue culture. The ongoing studies focus on the effect of viscoelastic properties on cell and organoid development. In the future, DyNAtrix can be used in basic research and personalized medicine, for example, to reproduce and investigate patient-derived tissue models in the laboratory.
Reference: Peng YH, Hsiao SK, Gupta K, et al. Dynamic matrices with DNA-encoded viscoelasticity for cell and organoid culture. Nat Nanotechnol. 2023. doi: 10.1038/s41565-023-01483-3
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