Researchers Prove that Insulin-Producing Cells can Give Rise to Stem-Like Cells In-Vitro
News Jul 28, 2008
The question of whether insulin-producing cells of the pancreas can regenerate is key to our understanding of diabetes, and to the further development of regenerative therapies against the disease.
Dr Rosenberg, from the McGill University Health Centre (MUHC), together with Dr Bernard Massie, a Universite de Montreal professor and researcher at the National Research Council Canada, have just concluded that they can. The results of their study have been published in the July issue of the journal Laboratory Investigation.
The researchers have shown in vitro that insulin-producing â-cells (beta cells) can return to a more primitive developmental state called stem-like cells. This process is known as “dedifferentiation” and highlights the plasticity of this cell type. This same result has also been validated for the three additional types of cells that; along with â-cells; make up the islets of Langerhans. Together, these islet cells produce insulin and other hormones in the pancreas.
“The potential for dedifferentiation of all the different cells that make up the islets of Langerhans is a totally new finding,” Dr. Rosenberg said. “At this stage, we can’t confirm whether the cells’ ability to turn into stem-like cells occur naturally in a healthy pancreas, but the results are very encouraging for the development of regenerative therapies to fight diabetes."
The cell’s in-vitro plasticity opens up totally new avenues of investigation into the underlying causes of diabetes, and will validate the development of innovative treatments. This study is the latest step in an extensive regenerative therapies research program based on a peptide called Islet Neogenesis Associated Protein, or INGAP.
Dr. Rosenberg and his colleagues have demonstrated INGAP’s potential to induce new islet formation in the pancreas. Clinical trials with INGAP have already demonstrated that it is possible to regrow new functional insulin-producing cells in diabetic patients. “We know that the peptide works, but we are still lacking certain theoretical bases to explain its mechanism,” said Dr. Rosenberg. “This finding will allow us to move ahead on firmer ground.”
Unraveling How Mesenchymal Stem Cells From Gum Tissue Accelerate Wound HealingNews
To assist with wound healing, mesenchymal stem cells from the gum tissue secrete extracellular vesicles that contain the anti-inflammatory signaling molecule IL-1RA.READ MORE
Mending Broken Hearts with Cardiomyocyte MoldsNews
A team of researchers at Michigan Technological University in collaboration with Harvard Medical School, shows how cardiomyocytes grown in a heart-like environment mature more quickly, have improved functionality and are less likely to be rejected by patients’ bodies.READ MORE
Engineered Cartilage Template to Heal Broken BonesNews
A team of UConn Health researchers has designed a novel, hybrid hydrogel system to help address some of the challenges in repairing bone in the event of injury.READ MORE