Researchers Track Cardiac Regeneration on Cellular Level
News Jun 20, 2013
Their findings provide evidence that various cell lines in the heart are more plastic, or capable of transformation into new cell types, than previously thought.
More importantly, the research reveals a novel potential source of cells for regenerating damaged heart muscle, according to principal investigator Neil Chi, MD, PhD, assistant professor of medicine in the Division of Cardiology and member of the Institute of Genomic Medicine at UC San Diego.
Heart failure remains the leading cause of death in the developed world, largely due to the inability of mammalian hearts to regenerate new cells and repair themselves. However, lower vertebrates such as zebrafish are capable of generating new ventricular heart muscle cells, or cardiomyocytes, that can replace the heart muscle lost through ischemia-induced infarcts — more commonly known in humans as heart attacks.
In this study, the scientists generated a genetic ablation system in zebrafish capable of targeted destruction of heart muscle, and then tracked both atrial and ventricular cardiomyocytes during injury using fluorescent proteins.
Using a genetic fate mapping technique — a method of comparing cells at various points of development in order to understand their cellular embryonic origin — the scientists revealed that cardiomyocytes in the heart's atrium can turn into ventricular cardiomyocyctes in a process called transdifferentiation. This transdifferentiation allows the atrial cells to regenerate and repair the ventricle, which is the chamber primarily affected in heart attacks.
First author Ruilin Zhang noted that such transdifferentiation was blocked when Notch signaling was inhibited, and subsequent studies will look at the Notch signaling pathway to understand the underlying mechanism at work.
"This is among the first studies to look at these specific cardiac lineages in detail to see how zebrafish are able to regenerate heart cells," said Chi, adding that their findings open a door to revealing how such regeneration might someday work to change the fate of human hearts.
Large-Scale Production of Living Brain Cells Enables Entirely New ResearchNews
After performing a biopsy on the patient, the skin cells are transformed into brain cells that effectively imitate the disease and the age of the patient.READ MORE
Innate Reaction of Hematopoietic Stem Cells to Severe InfectionsNews
Researchers at the University of Zurich have shown for the first time that hematopoietic stem cells detect infectious agents themselves and begin to divide, without signals from growth factors.READ MORE
Comments | 0 ADD COMMENT
EMBL Course: Transgenic Animals - Micromanipulation Techniques
Apr 10 - Apr 11, 2018
EMBO Practical Course: Extracellular Vesicles: From Biology to Biomedical Applications
Apr 09 - Apr 13, 2018
EMBO | EMBL Symposium: Tissue Self-Organisation: Challenging the Systems
Mar 11 - Mar 14, 2018
EMBL Course: Brillouin Microscopy: Emerging Tool for Probing Mechanical Properties of Living Cells
Jan 17 - Jan 19, 2018