Roche and Axiogenesis Enter into Co-Development and Marketing Agreement
News Dec 10, 2008
Roche and Axiogenesis AG have announced that they have entered into an agreement for the development and distribution for Axiogenesis’ Cor.At® 100% pure cardiomyocytes platform as an integral part of the xCELLigence life cell analysis system.
Under the terms of the agreement, RAS will market cell-systems, based on the technology of Axiogenesis Cor.At being customize for the xCELLigence platform.
The Roche xCELLigence System which is designed for a multitude of applications spanning from short term kinetic analysis, for example for measuring effects on G-protein coupled receptors (GPCRs), to assays for cell proliferation and cytotoxicity. The Cor.At® cells from Axiogenesis form an ideal couple to merge the latter qualities to the next level.
The cells are not only quality-controlled, storable and available under GMP-conditions but resemble also a physiologically normal phenotype of either neonate or adult heart. This couple therefore enables research studies focussing on long term life behavior of cardiac cells in vitro.
Financial terms of the contract were not disclosed.
“After completing our product portfolio in DNA/RNA analysis with 454 and NimbleGen, and the successful launch of the ACEA life cell and label free technology of the xCELLigence System the Axiogenesis cell portfolio will become an important partner to strengthen and further extend our product portfolio in defined organ specific cell analysis. We are convinced that Axiogensis Cell and Technology portfolio will lead to products for cell based assays to strengthen our new industrial standard for life science cell- analysis in the future,” commented Manfred Baier, Head of Roche Applied Science.
Bohlen expects that the major advantages of the technology of the xCELLigence System over conventional approaches will benefit from the Axiogenesis cell portfolio. “The system detects any number of cellular parameters such as attachment, spreading, growth, death, and specific morphological changes, simply and reliably."
The spatial and temporal dynamics of proteins or organelles plays a crucial role in controlling various cellular processes and in development of diseases. However, acute control of activity at distinct locations within a cell cannot be achieved. A new chemo-optogenetic method enables tunable, reversible, and rapid control of activity at multiple subcellular compartments within a living cell.