Sandcastles and Surprising Origins of Basic Cellular Functions
Cells comprising a tissue can pack into disorderly geometries much as do grains of sand in a sandcastle. In doing so they can freeze into a fixed shape—as in a sandcastle—or flow like sand poured from a beach bucket. The finding, reported by researchers at Harvard T.H. Chan School of Public Health, Northeastern University, and MIT, provides insights into organ formation in an embryo, healing of a wound, and even invasion of cells into surrounding tissue, as occurs in cancer.
“This finding makes a deep connection between the physics of inert granular matter such as sand and the geometry of multicellular living systems,” said lead author Lior Atia, a postdoctoral fellow in the laboratory of Jeffrey Fredberg, professor of bioengineering and physiology at Harvard Chan School. “Due to the nature of how a cell nestles among its immediate neighbors, a scientist can now look at cell shapes and make a reasonable guess as to why, and how fast, those cells will migrate, remodel, or invade surrounding tissues.”
The study appears online April 2, 2018 in Nature Physics.
Previous work by Fredberg and colleagues had documented the importance of collective cellular behavior in asthma, showing that cells comprising epithelial tissues—which line the surfaces of all organs throughout the body— can unjam and flow like a fluid, or jam and freeze like a solid.
In the new study, the researchers explored the role of cell shape in two vastly different types of epithelial cells—human bronchial epithelial cells grown in the lab and cells within the living embryo of the fruit fly—and observed them as they matured over time.
As cells jammed or unjammed, cell shapes changed in a systematic manner in both systems, thus suggesting a common physical basis. Cell shapes became progressively less elongated and less variable as they jammed, and more elongated and more variable as they unjammed. Much like inert granular matter, these cells interacted with their nearest neighbors to form a “disordered collective” that transitioned between solid-like and fluid-like states.
According to the researchers, these findings suggest that differences in shape from cell-to-cell within a tissue are key to their ability to jam and unjam—and that this process appears to drive biological events including embryonic development, wound healing, and, potentially, cancer cell invasion.
This insight into cell behavior could help researchers better understand cell jamming and unjamming, which could lead to potential treatments for conditions such as developmental abnormalities, asthma, and cancer.
This article has been republished from materials provided by Harvard T.H. Chan School of Public Health. Note: material may have been edited for length and content. For further information, please contact the cited source.
Targeting Epigenetic Proteins to Prevent Breast CancerNews
Researchers have discovered that epigenetic proteins promote the proliferation of mammary gland stem cells in response to the sex hormone progesterone. The study suggests that inhibiting these proteins with drugs could prevent the development of breast cancer in women at high risk of the disease.READ MORE
Cell Technology Used to Treat Osteochondral Knee DefectNews
Autologous cells of stromal vascular fraction were transplanted to a 36-year-old man with the use of fibrin matrix.READ MORE