We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
Scientists say Stem Cells from Female Mice Superior
News

Scientists say Stem Cells from Female Mice Superior

Scientists say Stem Cells from Female Mice Superior
News

Scientists say Stem Cells from Female Mice Superior

Read time:
 

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "Scientists say Stem Cells from Female Mice Superior"

First Name*
Last Name*
Email Address*
Country*
Company Type*
Job Function*
Would you like to receive further email communication from Technology Networks?

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

Women are superior in the world of mice when it comes to stem cells, according to Children's Hospital of Pittsburgh scientists.

Stem cells from the muscles of female mice, on average, were twice as good at growing muscle tissue as stem cells from male mice, researchers reported in the Journal of Cell Biology. They tested the use of stem cells gathered from muscle in mice with muscular dystrophy.

"For muscles, the female cells are clearly superior," said Johnny Huard, director of the Stem Cell Research Center at Children's and senior author of the journal article.

Huard began looking into gender differences when he noticed that most stem cells surviving after transplant at the center came from females.

The discovery means that stem cell scientists should consider the gender of stem cell donors when analyzing research results, said Amy Wagers, a scientist with the Harvard Stem Cell Institute who is familiar with the research but did not participate in it.

"I think it is an important variable to consider," said Wagers, who also is an investigator at the Joslin Diabetes Center in Boston.

But, because the results were variable, Wagers said, "I would interpret this cautiously. It's intriguing but focuses on one particular population."

Mice -- and people -- with muscular dystrophy have a genetic mutation that causes them to lack a protein called dystrophin, needed for muscle fiber to function normally. Researchers in several countries are hoping that by infusing healthy muscle-building stem cells into people with the disease, they will generate new dystrophin.

Unlike controversial embryonic stem cells, stem cells derived from muscle can only become muscle. Female stem cells might not be better across the board, said Huard, who is testing bone-derived stem cells.

Advertisement