Stem cells – generic cells that haven’t yet taken on specialized form and function – have recently been used by scientists at UBC and elsewhere to reverse Type 1 diabetes in mice. In Type 1 diabetes, which usually begins in childhood, the pancreas produces little or no insulin, the hormone that enables cells to metabolize sugar.
These new results, published today in Stem Cell Reports, hold much broader potential because Type 2 diabetes – which usually arises in adulthood and often stems from poor diet, lack of exercise and obesity – accounts for more than 90 per cent of diabetes cases.
Timothy Kieffer, a professor in the department of cellular and physiological sciences, and scientists from BetaLogics simulated Type 2 diabetes in mice by putting them on a high-fat, high-calorie diet for several weeks. Kieffer’s team then surgically implanted pancreatic-like cells that had been grown in the laboratory from human stem cells.
Mice that received a combination of the cells with one of three diabetes drugs became as “glucose tolerant” as the healthy mice, meaning they were able to keep their blood sugar in check, even after ingesting a sugary meal. In contrast, a group of mice with simulated Type 2 diabetes that received the drugs but not the transplants remained glucose-intolerant.
“Being able to reduce spikes in blood sugar levels is important because evidence suggests it’s those spikes that do a lot of the damage – increasing risks for blindness, heart attack, and kidney failure,” says Kieffer, a member of UBC’s Life Sciences Institute.
The combination therapy also produced an unexpected but welcome result: the mice returned to a normal weight, the same weight as the healthy control group mice that had been reared on a low-fat diet.
“Their weight loss was intriguing, because some of the common diabetes therapies often lead to weight gain,” Kieffer said. “We need to do more studies to understand how the cell transplants lead to weight loss.”
The team is also investigating if higher number of progenitor cells – beyond the five million tested in this study – can achieve the same results without the need for additional drugs.