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Is Ridding Cells of Stress Granules the Answer to Ataxia?

News   Sep 10, 2018 | Story sourced from the University of Utah Health

Stifling 'Staufen1' in Cells Improves Motor Function in Neurodegenerative Mice

Co-localization of Staufen1 with ATXN2 in stress-granule-like structures. ATXN2 and STAU1 co-localize in stress granules. Immunostaining of HEK-293 cells with antibodies against ATXN2, STAU1, and TIA-1 show co-localization of STAU1 with ATXN2 and TIA-1 in SGs during stress (0.5 mM sodium arsenite for 15 and 30 min) that are not present in the absence of stress. Scale bar, 10 µM. Credit: Paul et al 2018.



Mathematical Model Uncovers Long-Distance Cell Communication Mechanism


A new study has identified how a large community of cells can communicate with each other almost simultaneously even with very short distance signaling.


Does Smarter Mean More Stable? IQ Test Score Associates With Brain Network Stability


The interconnections and communication between different regions of the human brain influence our behaviour in many ways. This is also true for individual differences in higher cognitive abilities. The brains of more intelligent individuals, as measured by a standardised IQ test, are characterised by temporally more stable interactions in neural networks.


Mouse Study Can Explain How the Brain Turns Pain Up or Down


A new study in mice uncovered a previously unknown role that the central amygdala can play in upgrading or downgrading pain signals in the brain’s circuitry.



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