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Is Ridding Cells of Stress Granules the Answer to Ataxia?

News   Sep 10, 2018 | Story sourced from the University of Utah Health

Stifling 'Staufen1' in Cells Improves Motor Function in Neurodegenerative Mice

Co-localization of Staufen1 with ATXN2 in stress-granule-like structures. ATXN2 and STAU1 co-localize in stress granules. Immunostaining of HEK-293 cells with antibodies against ATXN2, STAU1, and TIA-1 show co-localization of STAU1 with ATXN2 and TIA-1 in SGs during stress (0.5 mM sodium arsenite for 15 and 30 min) that are not present in the absence of stress. Scale bar, 10 µM. Credit: Paul et al 2018.



Stem Cells Regulate Their Fate by Altering Their Stiffness


Reducing the number of cells participating in condensation — the clustering of stem cells prior to differentiation — leads to the activation of an intrinsic differentiation program. These findings open new avenues for stem cell therapies.


The 'Oops Centers' of the Brain


Psychiatrists diagnose people with mental illnesses by spending time with them, looking for the particular behavior symptoms of each. By deciphering the circuitry of the medial frontal cortex – an area beneath the top of the head — those diagnoses could become much more efficient and precise by allowing physicians to diagnose based on how neurons respond to a simple series of behavior tests.


Are Our Genetics Responsible for Our Addictions?


Scientists have concluded that the risk of addiction is a complex combination of both genes and environmental influences.



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