Study Finds Key Regulator in Pulmonary Fibrosis
News Oct 20, 2016
A Yale-led research team has identified an important enzyme that could lead to new therapies for a chronic fatal lung disease that affects hundreds of thousands in the United States each year.
Idiopathic pulmonary fibrosis (IPF) causes scar tissue inside the lungs, and patients may experience coughing and progressive shortness of breath. There is no cure for IPF. In a new study, the research team led by Yale Professor of Medicine Naftali Kaminski and by Marie Curie Fellow Dr. Argyrios Tzouvelekis explored the role of SHP2, an enzyme that removes phosphates from proteins and thus renders them inactive. The researchers found that the enzyme was low in lungs of humans with the disease.
In both cell culture and animal models of pulmonary fibrosis, the researchers found that suppression of the enzyme triggered pro-fibrotic changes in the lung, while increased enzyme activity prevented fibrosis. The findings suggest that SHP2 is an essential regulator and that potentially enhancing the activity or expression of it could provide a new therapeutic strategy for this deadly disease.
3-D Printed Sugar Scaffolds Offer Sweet Solution for Tissue EngineeringNews
University of Illinois engineers built a 3-D printer that offers a sweet solution to making detailed structures that commercial 3-D printers can’t: Rather than a layer-upon-layer solid shell, it produces a delicate network of thin ribbons of hardened isomalt, the type of sugar alcohol used to make throat lozenges.READ MORE
You Are What Your Mother EatsNews
While many factors, such as the age of the mother, overall health and genetics ultimately play a role, the correlation between a mother’s nutrition habits and metabolism has been proved to directly impact the growth of her child. And researchers believe they may be one step closer to knowing why.READ MORE
Comments | 0 ADD COMMENT
2nd Annual Artificial Intelligence in Drug Development Congress
Sep 20 - Sep 21, 2018