Texas Institute for Genomic Medicine to Sell Mouse Embryonic Stem Cell Clones for Research
News Apr 17, 2007
The Texas Institute for Genomic Medicine (TIGM) has expanded its product offering to include sales of mouse embryonic stem cell clones from the world’s largest collection of C57BL/6 and 129SvEv mouse lines. These mouse stem cell clones will be made available to scientists on a case by case basis.
TIGM maintains the world’s largest catalogue of embryonic stem cells for C57BL/6 mice, with more than 200,000 clones.
In addition, TIGM has contracted access to the largest catalog of genetically modified 129 mouse cells, with more than 272,000 stem cell clones available. TIGM uses these clones to create custom-designed breeding pairs of knockout mice that have specific genes altered especially for research.
“Scientists now have the option to build their own custom-designed breeding pairs of research mice by purchasing specific stem cell clones directly from TIGM,” noted Dr. Rick Finnell, TIGM president and executive director.
“However, creating successful germline transmission from clones is never a sure thing. Even in the hands of highly experienced scientists, the chances of creating customized mice with the exact gene modified is still in the 40-50% range. We continue to recommend that scientists purchase a breeding pair of mice from TIGM to ensure successful germline transmission,” Dr Finnell added.
In treating inflammatory bowel disease (IBD), physicians can have a hard time telling which newly diagnosed patients have a high risk of severe inflammation or what therapies will be most effective. Now researchers report finding an epigenetic signature in patient cells that appears to predict inflammation risk in a serious type of IBD called Crohn’s disease.