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Surgeons Share Insights on Building New Intestinal Tissue for Babies in Need

News   Jun 10, 2019 | Original story from The Saban Research Institute, Los Angeles Children's Hospital

The Big Picture on Growing Small Intestines

Fluorescent image of intestinal stem and progenitor cells. Cells like these can grow into engineered intestinal tissue in the laboratory. Eventually, Dr. Grikscheit hopes engineered intestine can help babies born with severe gastrointestinal challenges. Image credit: The Saban Research Institute, Children's Hospital Los Angeles



CRISPR Helps Find Cause of Rare Disease That Turns Babies’ Lips and Skin Blue


Scientists used a gene editing method called CRISPR/Cas9 to generate mice that faithfully mimic a fatal respiratory disorder in newborn infants that turns their lips and skin blue. The new laboratory model allowed researchers to pinpoint the ailment's cause and develop a potential and desperately needed nanoparticle-based treatment.


Size Matters for Genome Awakening in Embryos


Activation of an embryo's genome does not happen all at once; instead it follows a specific pattern controlled primarily by the various sizes of its cells.


A New Role for Cohesin Protein in Tumors and Rare Diseases?


Cohesin mutations have been identified in some types of cancer and in rare diseases referred to as cohesinopathies. Now, scientsits describe new functions of cohesin in mouse embryonic stem cells that might help understand and address the causes of these disorders.



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