We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Tracking How Herpes Simplex Virus Moves Through Cells

Tracking How Herpes Simplex Virus Moves Through Cells

Tracking How Herpes Simplex Virus Moves Through Cells

Tracking How Herpes Simplex Virus Moves Through Cells

Read time:

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "Tracking How Herpes Simplex Virus Moves Through Cells"

First Name*
Last Name*
Email Address*
Company Type*
Job Function*
Would you like to receive further email communication from Technology Networks?

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

The new research shows that HSV relies on a complex of proteins that mediate cargo capture in order to engage microtubules, the host cell’s intracellular transport network, to reach to the nucleus of a cell and replicate.

Using imaging techniques, Walsh demonstrated that before HSV moves using dynein, the virus depends on the dynamic nature of microtubules for capture. He observed that these microtubules, which dynamically grow and shrink to sense the intracellular environment, capture virus particles using specialized tracking proteins, EB1 and CLIP-170, at the tips of the microtubules.

“The virus actually sits at the periphery of the cell, and the proteins at the tip of the microtubules hook it and grab it on to the microtubule,” Walsh said. “Up until now, it would be assumed the virus could get on any part of the microtubule as long as it’s on a motor, but that doesn’t seem to be the case.”

This finding has “changed the way we think about how the virus gets on the microtubule,” Walsh said.

Furthermore, when the scientists observed other structures within the cell, such as proteins and organelles that depend on microtubules and motor proteins for transport, they found these structures do not need the tracking proteins EB1 and CLIP-170. This finding suggests that these specialized proteins that are required for HSV infection could serve as potential targets in the development of new antivirals.

In future research, Walsh plans to study the mechanisms of how the virus targets tracking proteins and engages microtubules.