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Whether you are working in cell line development, 3D biology, drug screening —or a combination of the three — technologies that maximize throughput and reproducibility can free up your time and give you greater insights.

Patient-derived induced pluripotent stem cells (iPSCs) enable generation of in vitro models that can recapitulate human disease phenotypes. However, conventional human iPSC differentiation protocols are often lengthy, inconsistent and difficult to scale.

To overcome these challenges, researchers have developed a proprietary gene-expression targeting strategy that can rapidly reprogram hiPSCs into pure somatic cell types in a scalable manner. This approach was used to develop a Huntington’s disease (HD) model carrying a 50CAG expansion in the huntingtin (HTT) gene.

Researchers require spatial information and high-plex gene expression data to understand how cells interact with tumors. However, molecular subtyping within a tumor type requires additional stratification at the tissue level to facilitate meaningful subsequent gene expression analysis.

Traditionally, there has been a compromise between performance and sustainability.

The NovaSeq X Plus system enables sequencing of >20,000 genomes per year and delivers data in half the time with a 2.5x improvement in throughput. Breakthrough advancement in chemistry, optics and software contribute to fast, highly accurate and cost-effective data.

Researchers looking to answer complex biological questions often require increased statistical power, larger studies and deeper sequencing methods.

The hypothalamic-pituitary-thyroid axis (HPT axis) is conserved across vertebrate evolution. Perturbation of thyroid hormone homeostasis (THH) can lead to adverse effects in thyroid function affecting growth, metabolism and cognitive function.

Insights and Expanding Practical Education in a Core Facility With Brightfield Imaging-Enabled Flow Cytometry

Membrane proteins are a notoriously difficult class of proteins to express, purify and characterize. Expression levels of membrane proteins in mammalian expression systems, the preferred system to generate native-like post-translational modifications, are often so low that yields are unsuitable for the intended downstream uses.

Researchers are always developing innovative applications for novel research areas, improving data quality and expanding the boundaries of experimental limitations.