Assessing Chemical-Mediated in Thyroid Function In Vitro
The hypothalamic-pituitary-thyroid axis (HPT axis) is conserved across vertebrate evolution. Perturbation of thyroid hormone homeostasis (THH) can lead to adverse effects in thyroid function affecting growth, metabolism and cognitive function. In utero, appropriate thyroid hormone concentrations are vital for normal nervous system development and a variety of experimental approaches are required to thoroughly investigate the effects of chemicals on thyroid function.
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