Cerebral Malaria Insights: Pathogenesis, Host Parasite Interactions including Host Resistance
Poster Dec 13, 2017
Lydia Anikin, Marc Bacarro, Ashton Hurley, Nathan Graham, Alyssa MacLeod, Amelia WinczuraLydia Anikin, Marc Bacarro, Ashton Hurley, Nathan Graham, Alyssa MacLeod, Amelia Winczura
The in depth clinical analysis of cerebral malaria includes a case study (hypothetical in this particular condition). We analyze the clinical conditions in different stages of Plasmodium falciparum infection in susceptible individual: A 3-year-old African-American boy was brought to the emergency department by his mother in a small town in Ethiopia. The child complained of a persistent headache for a few days. He eventually developed coughing, lethargy, generalized joint pain, nausea, vomiting and a high fever which came and went with shaking chills. The physician examined the patient, and he noted splenomegaly under left costal margin and upper left quadrant along with bilateral retinal hemorrhages on funduscopic exam. The patient was immediately admitted to the pediatric floor as the physician suspected malaria, a common disease in the local area. Blood work was drawn to measure the boy’s CBC, electrolytes, urea, creatinine, haptoglobin, lactic dehydrogenase and reticulocyte count. A lumbar puncture was done along with blood, urine, and sputum cultures plus a test for HIV. Dipstick tests for P falciparum histidine-rich protein-2 (PfHRP-2) antigen were positive. Following admission to the floor, the patient suffered a tonic clonic seizure which developed into status epilepticus. The boy was sedated and ventilated. He had a Blantyre coma score of 1, and he died hours later from septic shock.
Genome-wide association studies (GWAS) have identified more than 100 genetic loci associated with type 2 diabetes. The majority of these are located in the intergenic or intragenic regions suggesting that the implicated variants may alter chromatin conformation. This, in turn, is likely to influence the expression of nearby or more remotely located genes to alter beta cell function. At present, however, detailed molecular and functional analyses are still lacking for most of these variants. We recently analysed one of these loci and mapped five causal variants in an islet-specific enhancer cluster within the STARD10 gene locus. Here, we aimed to understand how these causal variants influence b-cell function by alteration of the chromatin structure of enhancer clusterREAD MORE
Human papillomavirus (HPV) vaccine rates continue to be low in the United States. Young women ages 18-26 years are eligible for catch-up vaccination but previous research shows that relationships status and percieved risk may be barriers to HPV vaccination. The purpose of this quantitative study was to assess the association between relationship status and perceived risk for HPV among young adult women.READ MORE
This abstract discusses three cases of pediatric heart transplant patients who suffered from parvovirus (B19) infection. Of these patients, two ( B & C) responded well to standard intravenous Ig therapy. Patient A however, did not respond to standard treatment and was begun on subcutaneous Ig, which effectively diminished his viral load. Thus, subcutaneous Ig infusions might serve as a second line treatment for transplant patients with parvovirus who do not respond well to the standard approach.READ MORE