Correlation between the stem cells differentiation and topography of Zinc oxide nanorods
Poster Oct 05, 2009
Since the conformation and symmetry may be equally important, we examine the order of nanorods on the surface to simulate the in vitro differentiation of stem cells and we revealed that stem cells respond differently to nanoscale features under the same conditions. Altering the orientation of nanotubular zinc oxide on the surface revealed changes in stem cell behaviour.
We found a distinct subpopulation of Tregs within BMSCs. Tregs and BMSCs in co-culture conferred neuroprotection that varied in a dose-dependent manner. Tregs minimized stem cell production of IL-6, a pro-inflammatory cytokine, and inhibited BMSC secretion of FGF-beta, a cytokine related to BMSC proliferation and differentiation. The ratio of Tregs found natively in BMSCs is optimally adapted to provide the maximum neuroprotective benefit of stem cell treatment after ischemic stroke.READ MORE