Mesenchymal Stem Cells: Coming of Age?
Poster Jun 16, 2006
Alexandra Stolzing and Andy Scutt
AbstractThe effects of aging on human mesenchymal stem cells, (MSC) were investigated. MSC were isolated from patients of different ages and the different parameters of aging were measured either immediately after isolation or after long-term cultivation in vitro. Markers of senescence were investigated, including p21, p53 and beta-galactosidase levels. Antioxidative defense capacity of the MSC were tested together with markers of oxidative damage and antioxidative enzyme activities. Also the changes in differential potential and numbers of MSC were investigated.
Assessment of Oral LISPRO Treatment in Ameliorating Amyloid and Tau Pathology in Transgenic Alzheimer’s Mice ModelPoster
Ionic co-crystals of lithium salicylate with organic proline (LISPRO) showed better safety and pharmacokinetic profile of lithium in plasma and brain of wild-type and transgenic Alzheimer mice model compared to lithium salts.READ MORE
CiPA Phase 2 Study: validation of an automated microelectrode array (MEA) assay of hiPSC-derived cardiomyocyte electrophysiology for cardiac safety evaluationPoster
These results support the use of hSC-CM and MEA technology for preclinical assessment of proarrhythmic risk within the proposed CiPA paradigm, and, more generally, demonstrate that automation of the CM-MEA assay can achieve high reliability and throughput for cardiac risk assessment in vitro.READ MORE
Monitoring Cell Health in Real-time / Time-lapse Cell-based AssaysPoster
The purpose here is to validate a novel far-red DNA binding viability probe, DRAQ7™, in real-time cell based assays for 2-D and 3-D models.READ MORE