PRESENTATION OF A NEW SOURCE FOR TEETH TISSUE ENGINEERING
Poster Oct 06, 2009
Tooth regeneration is a biological technique to solving problems of tooth loss. The detection of various stem cells in unerupted tooth buds, dental pulp or bone marrow has provided opportunities for their management in dentin-pulp repair. However, these cells types are limited by: availability, invasiveness of extraction and in some cases limited proliferative capacity. Herein we hypothesized that endometrial adult stem cells could be induced into odontoblasts.
We found a distinct subpopulation of Tregs within BMSCs. Tregs and BMSCs in co-culture conferred neuroprotection that varied in a dose-dependent manner. Tregs minimized stem cell production of IL-6, a pro-inflammatory cytokine, and inhibited BMSC secretion of FGF-beta, a cytokine related to BMSC proliferation and differentiation. The ratio of Tregs found natively in BMSCs is optimally adapted to provide the maximum neuroprotective benefit of stem cell treatment after ischemic stroke.READ MORE