The Expression and Activity of MMPs during Zebrafish (Danio rerio) Development
Poster Dec 16, 2008
Recent advances have made the zebrafish an attractive system for studying MMP activity. However, there are few commercially available antibodies against MMPs that are suitable for studies using zebrafish. The objectives of the study presented in the poster were to develop effective immunological reagents for the study of MMPs in zebrafish and to test commercially available narrow-spectrum fluorogenic MMPs substrates in in vivo zymography.
We found a distinct subpopulation of Tregs within BMSCs. Tregs and BMSCs in co-culture conferred neuroprotection that varied in a dose-dependent manner. Tregs minimized stem cell production of IL-6, a pro-inflammatory cytokine, and inhibited BMSC secretion of FGF-beta, a cytokine related to BMSC proliferation and differentiation. The ratio of Tregs found natively in BMSCs is optimally adapted to provide the maximum neuroprotective benefit of stem cell treatment after ischemic stroke.READ MORE