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A Single Source for 3D Cell Culture

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Greiner Bio-One will be exhibiting new kits for 3D cell culture at the European Biotechnica trade show for biotechnology, life sciences and lab technology in Hanover, Germany. The kits ­ which are being distributed in cooperation with Nano3D Biosciences, based in Houston, Texas in the United States ­ simplify the cultivation of cells into three-dimensional structures.

The physiological conditions of these types of 3D cultures are very similar to those in the body and thus allow for significant results for preclinical drug screening, toxicology and cancer research. With compatible cell-repellent surface cell culture vessels and microplates, Greiner Bio-One offers an ideal platform for Nano3D’s technology.

New technology for 3D cell culture

90 percent of all active ingredient candidates for cancer drugs fail due to low clinical effectiveness or highly toxic side effects in the clinical phase, i.e. at a very late stage in the development process. Three-dimensional in-vitro assays offer a promising method in high-throughput screening to enable a more conclusive evaluation of active ingredients at an early development phase.

Greiner Bio-One has partnered with Nano3D Biosciences to present innovative solutions for 3D cell culture. The 3D technology is based on magnetization of cells using nanoparticles that attach themselves to the cell membrane. Development of three-dimensional spheroids or ring structures is initiated by briefly applying magnets.

Ideal combination ­ Nano3D technology and CELLSTAR cell-repellent surface

Greiner Bio-One CELLSTAR cell-repellent cell culture vessels and microplates support three-dimensional cell growth by preventing adherent cell growth on the vessels’ surface. Kits allow rapid development of three-dimensional model structures as well as co-culture of various cell lines using standard media and laboratory equipment.

Easy-to-use in different formats, the platforms minimize risk of sample loss during experimental runs. Several studies have demonstrated that the magnetic particles have no effect on the growth characteristics and physiology of cells.

Kits contain CELLSTAR cell culture vessels with cell-repellent surface, a reagent to magnetize the cells (NanoShuttle) and the appropriate magnets. Most kit components are also available separately.