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Automated System for Generating Dendritic Cells

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Corning has launched Corning® MicroDEN, an automated perfusion cell culture system that provides a process for the differentiation of monocytes into dendritic cells.

The Corning® MicroDEN system enables the wide use of dendritic cells in cell and gene therapy for basic and applied research in immunology and immune-oncology. Developed by Flaskworks, the Corning MicroDEN system is now available from Corning.

The rise of personalized immunotherapies has increased demand for dendritic cells. However, the current process for generating these cells is cumbersome, error-prone, and time intensive. Dendritic cells are key elements in immunology and immunotherapy research in oncology and infectious diseases as well as autoimmune diseases and transplant rejection. The Corning MicroDEN system streamlines the process by minimizing the manual steps, resulting in more consistent yields, a reduced risk of contamination, and more efficient therapy research.

The Corning MicroDEN system is composed of the MicroDEN unit manufactured by Flaskworks, and closed-system consumables manufactured by Corning, such as tissue culture-treated polystyrene flasks, storage bottles, and tubing.