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UK Biobank Selects Trinean’s DropSense96™

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Trinean has announced that its DropSense96™ droplet reader has been chosen by UK Biobank for automated quantification of 500,000 purified DNA samples in its Genotyping project.

UK Biobank’s Genotyping project is one of the largest genetic studies, designed to better understand the complex interaction of lifestyle and genes in disease and personalized medicine. In collaboration with Affymetrix, genetic variations in 500,000 participants are being measured using a custom-designed Axiom™ genotyping array.

Samantha Murphy, Senior Project Manager (Genotyping) at UK Biobank, explains: “The DropSense96™ was selected in the DNA extraction workflow as it is readily automated and provided a means to extract and quantify a full plate of 96 samples in a single process, without the need for reagents. The DNA concentration and purity values are incorporated into export files from the DNA extraction systems for quick upload to our LIMS. The results from the DropSense96™ are used to decide if the samples are of sufficient quality to be shipped for genotyping.”

Yvan Sergeant, VP Commercial Operations of Trinean, adds: "The decision by UK Biobank to use our DropSense96™ droplet reader is a firm confirmation that our instruments are ideal for sample QC in genotyping workflows. Both the DropSense96™, tailored towards 96 well plate handling and the smaller Xpose™ reader fit for manual sample processing are unique in combining speed, an extensive measurement range and detailed sample content analysis beyond the possibilities of classic spectrophotometry. They are able to provide detailed and accurate sample info required in high-tech genetic testing”.