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Video Demonstrates Benefits of Controlled Nucleation
Product News

Video Demonstrates Benefits of Controlled Nucleation

Video Demonstrates Benefits of Controlled Nucleation
Product News

Video Demonstrates Benefits of Controlled Nucleation


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Using an example of freeze drying samples in vials the video on www.spscientific.com illustrates how ControLyo™ Technology enables the freezing step to be much more repeatable and allows potentially greater control over cycle optimization.

SP Scientific has signed a license agreement with Praxair, Inc. to utilize Praxair's ControLyo™ Nucleation On-demand Technology, which provides pharmaceutical and biotechnology companies with precise control over the freeze-drying process for drug developmental efforts.

This breakthrough technology was developed to specifically control the freezing step of lyophilization.  Freeze drying (also known as lyophilization) is a method of drying products whereby the material is frozen (made chemically inactive) and then placed under vacuum while energy, in the form of heat, is added so that the ice sublimates (goes directly from a solid to a vapour without entering the liquid stage) thus rendering the product stable at elevated temperatures.  Until now, the freezing step of lyophilization was uncontrolled due to the random nature of the nucleation or crystal-forming process. Praxair's new ControLyo™ technology now makes nucleation control a reality by regulating the nucleation temperature to within 1°C of its freezing point.  The results are improved product uniformity, quality and yield.

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