Automated Workflow Solutions for Enhanced Productivity
Featured Product Feb 28, 2019
Process automation that increases the amount of unattended runtime for analytical systems opens up opportunities to increase sample throughput and reduce development timelines. This whitepaper highlights technical and workflow considerations for those starting to automate their analytical systems. By using an automated strategy for ligand screening, the development time for projects was reduced from several months to a few weeks.
High throughput characterization systems can greatly accelerate discovery programs. However, the speed of an assay system is limited by its inputs – like the replenishment of samples and biosensors. By automating repetitive tasks in the workflow, users can achieve continuous operation without increasing operator time. The whitepaper, describing the integration of an Octet® HTX system into a development process characterizing the interaction of target molecules with newly developed affinity ligands, offers practical tips to avoid first-time mistakes in automation and over-engineering of solutions.
The Octet systems have no microfluidics components, which significantly reduces the complexity of the assays. This eliminates further time-consuming cleaning steps and reduces operating costs. In addition, it is a non-destructive measurement and the sample material, especially in the development process, is available for further experimental analysis.
Benefits of the BLI technology:
• Label-free, real-time results for kinetic characterization and quantitation of binding interactions
• Automated high throughput for up to 96 samples in parallel
• Low maintenance due to an microfluidic-free assay format
• Non-destructive measurement particular for precious samples
• High quality data also in crude samples such as cell lysates or culture supernatants
Read the whitepaper to discover some guidelines and avoid some of the pitfalls in over-engineering solutions rather than successfully realizing incremental improvements.