Product

ChipCytometry’s New CellScape™ Precise Spatial Multiplexing Instrument

CellScape™ is the next generation in ChipCytometry™ instrumentation, advancing the cutting-edge platform for quantitative in situ spatial phenotyping. ChipCytometry delivers single-cell targeted spatial proteomics for complex whole-tissue analysis of the tumor microenvironment, as well as deep immune profiling for applications in immunology, neuroscience, and infectious disease.

The new benchtop CellScape system builds on the existing core strengths of the original ChipCytometry instrument, the ZellScannerONE™, which has enabled spatial biology research with sub-cellular resolution and a large field of view suitable for whole slide pathology imaging, on both tissue samples and cell suspensions since 2016. The CellScape system, with its multiplexed fluidics integration, adds **complete walk-away automation, improved optical performance, sub-cellular resolution and massively increased throughput** for whole slide imaging of millions of cells, while maintaining the key features of the core ChipCytometry technology, including high-plex phenotyping with single-cell resolution, very high dynamic range imaging for detection and quantification of both high- and low-expressing targets, and compatibility with standard commercially available fluorescently labelled antibodies, requiring no proprietary antibody conjugation. This powerful combination of features will significantly improve researchers’ workflow, accelerate spatial biology discovery, and drive broader adoption of high-plex spatial omics for translational and clinical applications.

Product Specifications

Automation Autonomous image acquisition Autonomous sample staining & plex-iteration Autonomous coordination of multiple experiments Feasible Staining of 15 x 5 markers without Intervention

Throughput Four chip/sample parallel processing Greater than 320 mm2 available surface area per sample 1, 2, 3, or 4 parallel independent protocols Hot-swappable reagents for unlimited plex High-speed, encoded, XY,Z stages (sample/time experiment-dependent)

Optical Performance 20X Plan Apo Lambda D | 0.80 NA sub 405 nm to supra 750 nm chromatic correction 25mm+ planarity, relative to field number In-system registration correction (physical & digital)

Sample Illumination, Excitation Zero autofluor, monochromatic transmitted illumination Pan-spectral (inc. UV), high power arc lamp fluorescent excitation Five independent, zero required compensation imaging channels Target spectra: brilliant UV, brilliant V, FITC, PE, PerCP 5.5 Optimized, spectrally targeted, photo-inactivation channel

Digital Sampling 0.796 mm2 per image at 182 nm/pixel 2.714 mm2 per image at 365 nm/pixel (FalconFAST™ upgrade) High dynamic range image pipeline, 32-bit encoding luminance Transmitted, autofluorescence, & net fluorescence for all acquisitions

Image Analysis In system complete cytometry pipeline Automatic cell segmentation, automatic true NET FLUOR calculation Bivariate gating, gate-parent gate relational statistics, cell call - image linkage Imaging data compatibility with OME standards Cytometry data compatibility with FCS standards

Form Factor & Utility Requirements Compact benchtop scanner with compact benchtop fluidics unit In-built vibration isolation, VIT not required 120 V AC power

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