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An image of the Cyto-Mine® Chroma on white background
Credit: Sphere Bio


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Cyto-Mine® Chroma: Unmatched Single-Cell Analysis with Multiplexing Power

Cyto-Mine® Chroma: Unmatched Single-Cell Analysis with Multiplexing Power
Credit: Sphere Bio


Cyto-Mine® Chroma is a multiplexing-capable, fully-automated
single cell analysis platform that can encapsulate, analyze, sort, and dispense
viable single cells.

Leveraging picodroplet technology, single cells are encapsulated in tiny volumes of liquid (e.g.
cell culture media). Cyto-Mine® Chroma automates incubation of the cells
and cellular output, proliferation, and/or interactions can be measured using
standard fluor-based assays.

The automated system screens millions to tens of millions of
viable single cells and simple controls allow users to select and dispense
targeted desired cells for downstream outgrowth.

  • Multiplexing capabilities: Enables multiple readouts within a single experiment optimizing target cell selection
  • Picodroplet technology: Enables analysis of millions to tens of millions of single viable cells per experiment
  • Pre-loaded workflows and integrated control software: Ensures ease of use
  • Fluor-based readouts: Allows flexibility in experimental design



Product Specifications
Cell Analysis Throughput 2 Million cells per experiment (400,000 single cells or 40M pooled cells)
Chemistry Picodroplet encapsulation
Fluorescent Capabilities (Excitation / Detection) Up to 4 colors
Dimensions Main Instrument (w x h x d) 874 x 570 x 481 mm (34 x 23 x 19 in) Laser Module ( w x h x d) 314 x 158 x 493 mm (12 x 6 x 19 in)
Consumables Cyto-Cartridge®, Cyto-Surf® Reagents
Software On-board control, analysis, and data management software
Applications Cell Line Development, Antibody Discovery, Cell Therapy
About Sphere Bio
Sphere Bio develops and manufactures single-cell analysis and monoclonality assurance systems to enable researchers to find, analyze and isolate the most valuable cells, with ease and speed. Sphere Bio’s proprietary picodroplet microfluidic platforms are designed specifically for single-cell screening and isolation, allowing users to encapsulate and analyze single cells within a picodroplet, while maintaining viability. Harnessing this technology, the Company’s range of novel microfluidic tools facilitate leading-edge research and accelerate biotherapeutic discovery and development and cell therapy workflows, streamlining the journey of discovery in labs, globally. Sphere Bio is based at Granta Park in Cambridgeshire (UK). The Company has also internationalized its business via a global network of direct sales and support staff throughout the United States, Europe and experienced distribution channels across APAC.
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