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Cancer Genetics – News and Features

A person touching the genome.

Prime Editing Helps Scientists Screen the Effects of Cancer Mutations

Scientists at the Massachusetts Institute of Technology have developed a rapid gene-editing screen to explore the effects of cancer mutations.
Cancer cells.

Targeting Cancer-Fueling Proteins Shows Potential for Treating Aggressive Leukaemia

Researchers have found a new way to potentially treat one of the most common forms of acute lymphoblastic leukaemia. The study was able to kill leukaemia cells in the lab and stop cancer cells from growing.
A digital illustration of a DNA double helix.

Genetic “Dark Matter” Could Help Monitor Cancer

Researchers from the Johns Hopkins Kimmel Cancer Center have developed a machine-learning approach that identifies these sequences in both tumor DNA and cell-free DNA (cfDNA) that are shed into the blood.
The molecular structure of Trabectedin.

How a Compound From Sea Squirts Fights Cancer

Trabectedin, a promising drug derived from the sea squirt Ecteinascidia turbinata, has shown potential in combating cancers resistant to conventional treatments. However, its precise mechanism of action has remained elusive—until now.
A male patient with a doctor.

Understanding the Genetics of Male Breast Cancer

Male breast cancer represents less than 1 percent of all breast cancer cases each year. Unlike breast cancer in women, survival rates for men haven't significantly improved in the last 30 years, according to the National Cancer Institute.
Red cancer cells adhered to a grey surface.

Tumor Heterogeneity: Navigating the Next Frontier in Cancer Research

Some types of cancer are still extremely challenging to successfully treat. Once the disease has spread, it is very hard to cure. This article will explore the various types of tumor heterogeneity, how heterogeneity can impact treatment resistance and its influence on precision medicine.
A brain with white networks that look like smoke.

Agent Orange Exposure Mirrors Alzheimer's Impact on Brain Tissue

Exposure to Agent Orange, a herbicide used in the Vietnam War, has been shown to mirror the effect of Alzheimer's disease on the brain.
Immunofluorescence image shows small cell lung cancer spreading throughout the bronchioles.

One Type of Lung Cancer Can Turn Into Another, Study Finds

Lung tumors called adenocarcinomas sometimes respond to initially effective treatments by transforming into a much more aggressive small cell lung cancer (SCLC) that spreads rapidly and has few options for treatment.
Cancer cells.

Discovery Could Lead to “Double Blow” Against Cancers

A multinational team of researchers led by Columbia University has discovered that tumors can repurpose a single cellular protein to hide themselves from the immune system in two distinct ways.
Breast cancer cells.

Novel Drug Targets Aggressive Breast Cancer

A promising drug could lead to a new treatment for the most aggressive form of breast cancer, which affects thousands of women each year. A pre-clinical study found the new drug successfully inhibits the growth of triple negative breast cancer.