Spatial Biology – News and Features

Natural killer T cells could be used to produce antitumor activity in solid tumors.

A multicenter study found that different KRAS mutations in pancreatic ductal adenocarcinoma affect patient survival outcomes. The KRAS-G12D mutation correlates with aggressive cancer.

A study shows that the CAR-T cells of long-term survivors of acute lymphoblastic leukemia exhibit a distinct type 2 immune response, linked to increased remission rates. A second study indicates that modifying IL-4 can enhance T cell metabolism.

Brown University scientists present a new mass spectrometry technology that overcomes a major limitation of electrospray ionization (ESI) – sample loss.

New research challenges the traditional view that low oxygen levels in tumors only contribute to cancer progression, highlighting a potential new strategy to harness the body’s immune system to fight cancer more effectively.

A study shows that SARS-CoV-2 triggers immune cells to destroy insulin-producing beta cells, potentially inducing diabetes. Researchers used pancreatic tissue from COVID-19 patients and innovative organoid models to uncover this mechanism.

Single-cell analysis offers a unique perspective of the genetic and molecular features of individual cells. In this article, two early adopters of single-cell analysis technologies highlight some of the latest advances and new applications.

This article examines how next-generation sequencing and state-of-the-art imaging technologies are being combined to characterize and map the spatial organization of cell types in tissues.

Interim data from the Phase I dose escalation part of the mRNA cancer immunotherapy (mRNA-4359), show promise in patients with advanced solid cancers.

A new discovery confirms that a key molecule can reprogram immune cells that normally protect against infection and cancer, turning them into bad guys that promote cancer growth.