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Therapeutic Delivery – Multimedia

Addressing the challenges of poor solubility: Rapid development and clinical evaluation of a lipid based formulation to enhance oral bioavailability of amuvatinib (MP-470) content piece image
Poster

Addressing the challenges of poor solubility: Rapid development and clinical evaluation of a lipid based formulation to enhance oral bioavailability of amuvatinib (MP-470)

Physiochemical and biopharmaceutical properties of new chemical entities are presenting increasing challenges to successful oral drug delivery. Here we present data on amuvatinib, a novel multi-targeted tyrosine kinase inhibitor specifically designed to be a potent inhibitor of mutant c-Kit and PDGFRalpha.
Characterizing a Nasal Spray Formulation from Droplet to API Particle size content piece image
Poster

Characterizing a Nasal Spray Formulation from Droplet to API Particle size

Interaction of a nasal spray product with the patients’ body depends on key variables such as the particle size of the delivered droplets and the suspended active pharmaceutical ingredient (API). The particle size of the drug can be an important parameter for the rate of dissolution and availability to sites of action within the nose.
Use of gamma scinitigraphy to understand inhaled device/formulation variables on delivery efficiency and content piece image
Poster

Use of gamma scinitigraphy to understand inhaled device/formulation variables on delivery efficiency and

Systemic delivery of both small molecules and macromolecules via inhaled therapies is an area of significant ongoing research1. The pulmonary route offers the physiological benefits of a highly vascularised, large surface area for absorption which can promote high bioavailability and a rapid onset of action. For biomolecules such as peptides, proteins and nucleic acid derivatives, inhaled drug delivery can also provide a viable alterative to intravenous administration.
Rapid Solution Exchange and Ligand-Gated Channel Studies on the PatchXpress 7000A Automated Patch Clamp System content piece image
Poster

Rapid Solution Exchange and Ligand-Gated Channel Studies on the PatchXpress 7000A Automated Patch Clamp System

The PatchXpress® 7000A patch clamp system is an automated electrophysiology workstation that allows users to increase throughput of research quality recordings and to measure ion channel activity from nearly any channel type.
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