Single-cell RNA sequencing is a powerful technology that can reveal a lot about what happens in a group of cells as they develop.
But because the technology destroys a cell, it can only provide snapshots of the cells in a group at one point in time.
To really understand how cells develop over time, snapshots aren't good enough: scientists want to fill in the gaps between snapshots and string everything together into a movie.
Here Geoffrey Schiebinger explains how he and colleagues have figured out how to do just that, by tapping a powerful 18th century mathematical method called optimal transport.
Learn more about what Schiebinger and other Broad scientists are doing with optimal transport here.
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When a cell divides to make new cells, the chromosomes normally stay the same. But sometimes mistakes happen. With Philadelphia positive leukemia, a gene called the ABL1 gene on chromosome 9 breaks off and sticks to a gene called the BCR gene on chromosome 22. It produces a new gene called BCR-ABL1 which causes the cell to make too much of a protein called tyrosine kinase. This protein encourages leukemia cells to grow and multiply.
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