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Evo-Devo (Despacito Biology Parody) - A Capella Science

Evo-Devo (Despacito Biology Parody) - A Capella Science

Evo-Devo (Despacito Biology Parody) - A Capella Science

Evo-Devo (Despacito Biology Parody) - A Capella Science

This is how we go from single cells to people.



B. Mac.

Oh Carroll, Carroll

Gould, Stephen Jay yeah

D-D-D-D-Davidson and Peter


One cell divide and decide on a thousand fates

Did you ever figure how they know?

B. Mac.


Are built of modules combined in a planned out way

Each new piece must be told where to go


Now there's a science helping us to understand

How our cells encode this architectural plan

Signalling each other with genetic tools oh

Oh yeah


Phenotype the interface for mouse and man

Genotype the files and the subprograms

What then are the switches, circuit boards and boot code?


Looking at the logic in the ways that we grow

Every gene directed by a signal key code

Proteins that can activate, enhance or veto


Signals are controlled by other genes that signal

Calculating in a network labyrinthal

Where the heart and liver and the hands and feet go

Signal mapping tells each region what it ought to be yo

With circuits so deeply built upon

They're older than the Paleo

The Paleozoic Era baby

In a crucial pathway changes tend to get torpedoed

Where they go calamity goes

As this cyclopic sheep knows..

See down they cascade like a domino

Like you and I drosophila

The path that makes us optical

Was laid a long long time ago

Back before we blew up the cambrian like a bomb bomb

Now my eye protein can make you see out of your bom bom

And Hedgehog and its relatives like Indian and Sonic

Set up set up in a gradient on segments embryonic

Split forebrains and asymmetric parts depend upon it

Flipping on genetic switches and logic

From devo to evo

Adult and embryo

Mostly don't evolve in the genes of the genome

Safer the mutation aimed at regulation

Keep the building blocks and swap their activation

From devo to evo

Parts have alter egos

Homologs evolved from repeats in the schema

Switch a couple bases in the proper places

You'll be watching flies grow legs out of their faces oh yeah


Stick around for Modern Synthesis the sequel

Only by combining can a new theory grow

Evolution and development amigos


Signals trigger patterns of complexity so

Switching up the switches of a signalling node

Gives a modular and simple way to evolve

Look at how our spinal segments generate a neat row

Built on a molecular clock

One cycle, one vertebra

One vertebra one vertebra baby

Speeding up its rate is snakes' developmental cheat code

That and where a lizard's feet grow

They turn off distal aminos


This is how we go from single cells to people

Every generation and in life primeval

Life in variations endless and beautiful


From devo to evo

Larva to mosquito

Patterns are resolved as the signals proceed yo

Map out a gene with a glow tag

Kill it with a morpholino

Short oligo morpholino baby

From devo to evo

Voyage of the Beagle

Body plans evolve when proteins steer the genome

In this manner life's beauty grows

Aesthetica in vivo