We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience, read our Cookie Policy

Stem Cell Derived Cardiomyocytes in Drug Safety Evaluations: Lessons Learned from the Comprehensive in Vitro Proarrhythmia Assay (CiPA) Initiative

Video   Oct 18, 2016

 

The Comprehensive in Vitro Proarrhythmia Assay (CiPA) represents a new paradigm for directly assessing proarrhythmic risk based upon mechanistic assessments of cellular proarrhythmia linked to Torsades-de-Pointes proarrhythmia. Human stem cell derived cardiomyocytes (hSC-CMs) play a critical role in this initiative, serving to confirm in silico reconstructions of electrophysiologic effects of drugs. The utility of this approach involves consideration of the higher throughput approaches to be used (multielectrode arrays or voltage-sensing optical technologies) as well as consideration of the ability of hSC-CM’s to faithfully and reproducibly recapitulate cellular proarrhythmic events. Multiple publications (as well as a HESI-CiPA Pilot study) point to the utility of hSC-CM’s to detect delayed repolarization as well as other repolarization abnormalities. However, such studies are typically small and conducted unblinded, with a potential bias in the selection of test agents that may not be fully characterized in regards to proarrhythmic risk ranking. Evolving datasets from an ongoing validation study with hSC-CM’s will provide an assessment of the utility of hSC-CM’s for evaluating proarrhythmic liabilities early in drug discovery as well as in later regulatory-approvals of new drugs.

 
 
 
 

Recommended Videos

Researchers love this microplate spectrophotometer - Thermo Scientific Multiskan Sky

Video

Plate reader with ready-made protocols, cloud connected, touch screen, no learning curve. Researchers from the University of Helsinki Pharmacy dept. review the Thermo Scientific Multiskan Sky Microplate Spectrophotometer as efficient and easy-to-use.

WATCH NOW

How Can We Make Brain Tumor Immunotherapy Effective?

Video

A bone marrow-derived progenitor cell population has been identified, which can alter the tumor microenvironment and enhance anti-tumor responses.

WATCH NOW

Caught in the Act: Key Moments in Cell Death Captured

Video

Dr. Peter Czabotar of the Walter and Eliza Hall Institute, Australia, discusses his discovery of how a key molecule, Bax, changes its shape to drive cell death.

WATCH NOW

 

Like what you just watched? You can find similar content on the communities below.

Drug Discovery

To personalize the content you see on Technology Networks homepage, Log In or Subscribe for Free

LOGIN SUBSCRIBE FOR FREE