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Predictive Toxicology: Organ-Chips Demonstrate Superior Performance to Animal Models and Spheroids
Webinar

Predictive Toxicology: Organ-Chips Demonstrate Superior Performance to Animal Models and Spheroids

Predictive Toxicology: Organ-Chips Demonstrate Superior Performance to Animal Models and Spheroids
Webinar

Predictive Toxicology: Organ-Chips Demonstrate Superior Performance to Animal Models and Spheroids

Jack Scannell, PhD
Jack Scannell, PhD
Managing Director, JW Scannell Analytics Ltd, Author or Eroom's Law
Lorna Ewart, PhD
Lorna Ewart, PhD
Chief Scientific Officer, Emulate
Daniel Levner, PhD
Daniel Levner, PhD
Co-Founder, Board Member, CTO at Emulate

Failure in late stages of the drug development pipeline is one of the major challenges that the pharmaceutical industry faces today. Human organ-on-a-chip (Organ-Chip) technology has the potential to disrupt preclinical drug discovery, as it has been shown to recapitulate organ-level pathophysiology and clinical responses. Additionally, industrial guidelines have been published that describe the criteria for qualifying preclinical models for a particular use application; however, systematic and quantitative evaluation of Organ-Chips’ predictive value has not been conducted to date.

To explore how this challenge might be approached, 780 human Liver-Chips were analyzed to determine their ability to predict drug-induced liver injury caused by small molecules. Across a blinded set of 27 known hepatotoxic and non-toxic drugs, the Liver-Chip demonstrated a sensitivity of 87% and a specificity of 100%.

Watch this webinar to discover: 

  • Why preclinical models with greater predictive validity will improve clinical success and productivity
  • How the Emulate Liver-Chip performed against the IQ MPS guidelines and compared to animal models as well as hepatic spheroids
  • What the economic impact of the Liver-Chip in routine use of small-molecule liver toxicity could be
  • Where the Emulate Liver-Chip can be implemented into the drug development process
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