Latest App Notes & Case Studies

App Note / Case Study
Whole-Mount Slide Imaging in Traumatic Brain Injury Research
This application note describes how the TissueScope™ solution provides researchers with the opportunity to effectively map the entire brain, and link detailed cytoarchitectural maps with functional imaging data.

App Note / Case Study
Ensuring Sectioning Quality in TMA Analysis for the Human Protein Atlas Project
This article describes how the tissue microarrays and slides are made, and how a rotary microtome with different cutting modes and an automated Section Transfer System together ensure that high-quality, reproducible sections are generated.

App Note / Case Study
Sectioning of Bone as a Specialist Histology Specimen
This application note discusses how the Thermo Scientific HM355S and Finesse ME+ Automated Microtomes deliver quality sections from bone tissue.

App Note / Case Study
Proteomic Analysis of Laser Microdissected FFPE Tissue Using Mass Spectrometry
This application note discusses a study which was undertaken to identify candidate protein biomarkers for early detection of endometrial cancer using formalin fixed paraffin embedded tissue samples.

App Note / Case Study
Mass Spec Protein Assays in FFPE Tissue
This application note discusses how the Liquid Tissue®-SRM platform makes possible quantitation of proteins and their phosphorylation states by mass spectrometry using small amounts of laser microdissected FFPE tissue.

App Note / Case Study
Triggering with the Leica TCS SP5, TCS SP5 II and DM6000 CFS
This document provides detailed information about triggering with the Leica TCS SP5, TCS SP5 II and DM6000 CFS systems.

App Note / Case Study
On-screen Analysis: Review Captured Cells on-Screen
This application note shows the methodology for viewing and evaluating captured cells on screen.

App Note / Case Study
Sample preparation with the AC Extraction Plate: extraction of urinary THC metabolites for LC-MSMS quantification
In many countries, routine workplace drug testing involves screening for the free THC-COOH metabolite obtained by hydrolyzing THC-COOH glucuronide.
Tecan’s AC Extraction Plate with TICE technology enables a straightforward workflow that is reproducible and cost efficient. Liquid chromatography coupled with tandem mass spectrometry (LC-MSMS) provides an easy and cost-effective means for fast, sensitive and precise analysis of THC and its metabolites.

App Note / Case Study
Automated sample preparation for the determination of testosterone in serum by LC-MSMS
For accurate, reproducible quantification of testosterone, a growing number of laboratories are shifting from immunoassay to liquid chromatography coupled with tandem mass spectrometry.
This application note describes the preparation of serum samples for subsequent LC-MS analysis of testosterone, focusing on a streamlined workflow suitable for automation.

App Note / Case Study
Validating the Expression Consistency of a Housekeeping Protein
Housekeeping proteins (HKP) are typically used as loading controls because it is assumed that the HKP expression level remains consistent across samples. However, there is evidence that HKP expression levels change in many scenarios, including siRNA treatment, cell death, cell differentiation, etc.
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