Achieve Robust Quantification of Antibody-Dependent Cellular Phagocytosis
Application Note Feb 25, 2021
Antibody-dependent cellular phagocytosis (ADCP) is the immunological process of antibody-stimulated engulfment of cancer cells by phagocytic immune cells. Monoclonal antibodies (mAbs) are used extensively as cancer therapeutics due to their ability to induce selective killing of cancer cells. An important stage in the development of therapeutic mAbs is the characterization of their effect on ADCP. However, this can be challenging as conventional techniques for measuring ADCP can have complex and time-consuming workflows, lengthy fixation protocols, quantification issues etc.
Download this app note to discover a high-throughput, multiplex assay that:
- Can profile large libraries of mAbs for their effects on ADCP in minimal time
- Reduces the time for MoA characterization in drug discovery applications
- Relies on a simplified, streamlined workflow with inbuilt, automated data analysis