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Efficient Removal of Aggregates From Monoclonal Antibodies

Antibody Aggregates

Monoclonal antibody (mAb)–based therapeutics have been successful in helping treat various diseases, including cancer. The manufacturing of these therapeutic antibodies is a complex operation with low levels of aggregates being a critical quality attribute of the final product, as this will impact the biological activity.

Therefore, the efficient removal of aggregates from the final therapeutic product is of great importance. Hydrophobic interaction chromatography is a versatile purification technique that can be utilized to remove aggregates in the downstream processing of mAbs. 

Download this app note to discover a method that displayed:

  • Significant reduction of mAb HMW aggregate and dimer, achieved under low-conductivity conditions 
  • >99% purity, and 98% monomer recovery at a load density three times higher than the mixed-code conditions
  • Fast mass transfer and high performance at high flow rates
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