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Quantify 500 Plasma Proteins in 11.5 Minutes Using timsTOF Pro With PASEF and 4D Feature Alignment
Application Note

Quantify 500 Plasma Proteins in 11.5 Minutes Using timsTOF Pro With PASEF and 4D Feature Alignment

Quantify 500 Plasma Proteins in 11.5 Minutes Using timsTOF Pro With PASEF and 4D Feature Alignment
Application Note

Quantify 500 Plasma Proteins in 11.5 Minutes Using timsTOF Pro With PASEF and 4D Feature Alignment

The unique characteristics of the timsTOF Pro with PASEF allow routine measurements of ion mobility information and enable high quality 4D feature alignment in retention time, m/z and ion mobility (1/K0) and MS1 intensity.

Quantitiative analysis by immunoassays are limited in the number of proteins or analytes that can be measured simultaneously. Whilst mass spectrometry (MS)-based proteomics provides an attractive alternative, there are a number of challenges that make it difficult to implement.

Download this application note to learn more about:

  • The limtiations of LC-MS/MS-based proteomics
  • How the timsTOF Pro with PASEF and Evosep One facilitates biomarker discovery in large sample cohorts
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