We spoke to Dr Philippe Taniere, Consultant Histopathologist/Molecular Pathology, and Dr Matthew Evans, Specialist Registrar at University Hospitals Birmingham, to learn how the role of pathologists is changing, what this means for oncologists and cancer patients, and some of the challenges these changes may present.READ MORE
Despite regulation and legislation regarding the methods by which pharmaceutical companies must treat waste water, reports indicate that manufacturers are continuing to discharge untreated or inappropriately treated waste into the environment. The problem is having devastating impacts on human health, the environment and antimicrobial resistance is soaring.
Capillary electrophoresis-mass spectrometry (CE-MS) has remained in the shadows for decades. However, this powerful separation technique is now enjoying a renaissance, with academic and industrial scientists keen to exploit its key advantages. We spoke to some of its most ardent fans to explore a variety of the latest research and clinical applications.READ MORE
Based on the analysis of cells, genes, and chemical signals in body fluids, liquid biopsies provide timely, actionable information on disease states while eliminating the high cost and risks of tissue biopsies. Gene amplification through polymerase chain reaction and related techniques offer these benefits with the added advantage of amplifying low-abundance species. This article looks at the state of the art in PCR-based liquid biopsies, including a discussion of the technique's limitations.READ MORE
The fight against antibiotic resistance is real and is something we all have a responsibility in tackling. In fact, antibiotic resistance kills an estimated 700,000 people each year and has fuelled the re-emergence of illnesses that had become a rarity in many parts of the world.READ MORE
In this article, we provide practical guidance for the application of differential scanning calorimetry (DSC), a core technique for studying the stability and higher order structure (HOS) of proteins. We explain how DSC works, and highlight good practice for ensuring optimal data quality. The interpretation and value of the resulting data is also discussed.READ MORE
The imaging of biological samples, or bioimaging, plays a key role in current life science research, enabling scientists to analyze molecules, cells and tissues from a range of living systems.READ MORE
Mass spectrometry has evolved as a prevailing technique for both the characterization of biotherapeutics and identification of protein variants and post-translational modifications.READ MORE
Since its origins in the 1960s, the biosensors field has grown to encompass a wide range of sensors, from enzyme-based to immunosensors to DNA biosensors. Along with this, a diverse set of applications have flourished, with biosensors finding roles in food safety, medical diagnostics, and environmental analysis to name just a few.
Aflatoxins have been an issue in food and feed since the 1970’s, but the first global effort to regulate them took place in 2003. Aflatoxin B1 is by far the most prevalent and potent sub-type. Accordingly, maximum levels for B1 are set lower than total aflatoxin levels which highlights the need to test these two measures independently.READ MORE