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High-Throughput Screening Techniques To Improve Cellular Drug Discovery

New high-throughput screening methods are unlocking the potential of immune and stem cells to drive more effective cell-based therapies.

Article  
Published: April 9, 2025 
Andy Tay, PhD
 speaking with 
Lih Feng Cheow, PhD
 & Dino Di Carlo, PhD
High-throughput screening process in a laboratory, featuring a pipette dispensing liquid into a petri dish among automated testing equipment.
Credit: iStock

Traditional drug development has long relied on small molecules and antibodies, but a new frontier is emerging – cell-based therapies. From immune cells that attack cancer more effectively to stem cells that promote tissue regeneration, the ability to identify and optimize the most potent cell populations is transforming medicine.


Breakthroughs in high-throughput screening and AI-driven sorting are unlocking unprecedented potential, but challenges remain. Read on to explore how the latest innovations are revolutionizing cell-based drug discovery and what this means for the future of precision medicine.

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Meet the Author
A greyscale headshot of Andy Tay
Andy Tay, PhD
Assistant Professor of Biomedical Engineering
Andy Tay holds a PhD from the University of California, Los Angeles. He completed his postdoctoral training at Stanford University where he developed nanotechnologies for immuno-engineering. Andy Tay is currently a Presidential Young Professor at the National University of Singapore. His lab is dedicated to developing innovative approaches for cancer immunotherapy and tissue repair.
Interviewing
White letters "LFC" on a navy background.
Lih Feng Cheow, PhD
Assistant Professor
Lih Feng Cheow is an assistant professor in the Department of Biomedical Engineering at the National University of Singapore (NUS) and a Principal Investigator at the Institute of Health Innovation and Technology (iHealthtech). His research focuses on developing cutting-edge technology platforms for precision measurement of multiple parameters in individual cells.
A greyscale headshot of Dino Di Carlo
Dino Di Carlo, PhD
Armond and Elena Hairapetian Professor of Bioengineering
Dino Di Carlo is the Armond and Elena Hairapetian Professor of Bioengineering at UCLA, serial entrepreneur and inventor. He also serves in academic leadership roles as the Chair of the Bioengineering Department and Deputy Director of a National Science Foundation Engineering Research Center. He received his BS and PhD in Bioengineering at UC Berkeley and UCSF.
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