We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
A New Tech for Gene Study
Industry Insight

A New Tech for Gene Study

A New Tech for Gene Study
Industry Insight

A New Tech for Gene Study


Want a FREE PDF version of This Industry Insight?

Complete the form below and we will email you a PDF version of "A New Tech for Gene Study "

First Name*
Last Name*
Email Address*
Country*
Company Type*
Job Function*
Would you like to receive further email communication from Technology Networks?

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

Scientists from the North Carolina School of Medicine have developed a new technology for gene studies, making the process of gene research much easier without gene knockout while bringing higher accuracy. The tech applies an optogenetic tool to mark and control proteins.

The traditional method for learning what a gene codes for it  tracking the protein it relies on to express its character, however, identifying the protein can be quite sophisticated as it can’t be targeted at the very first time and need to track several proteins. The new tech involves employing the laser to manipulate the movement of proteins after the protein is labeled with light-responsive switches.

With the laser control, proteins can be moved to the cytoplasm from the cell nucleus and out of its normal function, then if the gene related activities change or disappear, the protein would match the gene, eliminating the complicated process of knocking out the gene of interest which is much more difficult than manipulating proteins.

The new technology avoids the problem that cells get used to the lives without a certain gene before the target gene is really picked out. Besides, it provides more access for experiment time.

The research team found the early version of the tech from a plant protein AsLOV2 whose activities are influenced by light. When in light, the protein will be released into cytoplasm from nucleus. Then they applied the mechanism into animal cells. Researchers embedded a light switch in protein LexA and Bre1, and things went in the same way with the previously plant protein. After being exposed to light, the proteins were released from the neucleus.

Another great finding from this research is that the cellular activities are much stronger than that was thought in the past.

The study paper is published in the journal of Nature Chemical Biology, titled as Light-induced nuclear export reveals rapid dynamics of epigenetic modifications, with DOI number being 10.1038/nchembio.2068, and can be accessed at Nature Chemical Biology with closed entry.

Author Bio


Creative Bioarray is a professional supplier for cells (human adult stem cells, tumor cells, and etc), and sub products including tissue array, probes and related equipments. With more than ten years’ experience in the field, the company is endearing to become a comprehensive platform for cells products and communication.
Advertisement