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Jonathan Dornell, PhD profile page

Jonathan ""Jd"" Dornell is an entrepreneurial research scientist working to better understand how nature influences our health and wellbeing. His expertise includes the application of genetic, biochemical, and microbiological tools to develop solutions for broadly relevant problems. A life-long student, Jd’s outlook drives his ability to generate innovative concepts in not-so-obvious ways.

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Published Content
Total: 11
A diagram of a cross-section of skin, with the different layers and features labelled.

The Skin Microbiome

Human skin is an ecosystem for billions of microorganisms that colonize each fold, crease and niche from head to toe. In this article, we describe what the skin microbiome is, which microorganisms are part of the skin microbiome and how we’ve come to understand the various relationships between the human skin and its microbial residents through advanced genomics.
Monoclonal vs Polyclonal Antibodies

Monoclonal vs Polyclonal Antibodies

Antibodies are immunological proteins that play fundamental roles in host defense against infectious agents such as viruses, bacteria and fungi. Two types of antibodies – polyclonal and monoclonal – provide research scientists with distinct ways to detect or quantify target antigens largely due to differences in specificity and affinity. In this article, we describe polyclonal and monoclonal antibodies in more detail and consider how each type may be used for various applications.
Chunks of DNA ready to be spliced.

Alternative Splicing: Importance and Definition

Discovered in the 1970s, the mechanisms of RNA splicing have been well characterized through numerous studies in eukaryotic and prokaryotic systems. In this article, we describe the mechanisms of alternative splicing and further explore its role in molecular biology.
A person receiving a vaccine in their arm and a multiwell plate being filled with liquid.

In Vivo vs In Vitro: Definition, Pros and Cons

In this article, we will define the terms in vivo and in vitro and further evaluate the pros and cons of analysis using these methods with detailed examples.
cfDNA molecules in the bloodstream.

What Is cfDNA?

In this article, we will define what circulating free DNA are and how these biomarkers are analyzed in the clinic.

CD8+ T Cell differentiation

CD8+ T Cells

T cell lymphocytes play a critical role in cell-mediated processes that underlie adaptive immunity. In this article, we focus on CD8+ T cells by characterizing their immunological phenotypes and the processes behind their cell-mediated immune functions.
A diagram showing the action of RNA polymerase.

RNA Polymerase: Function and Definition

Ribonucleic Acid (RNA) polymerase is an intermediary enzyme responsible for processing gene sequences into RNA-based genetic material that can be utilized in protein synthesis. In this article, we define RNA polymerase and further explore its various functions throughout cell biology.

Illustration showing the various stages of pharmaceutical development.

What Is DMPK (Drug Metabolism and Pharmacokinetics)?

The competitive landscape throughout the drug development process requires research scientists to apply rigorous qualitative and quantitative analyses to bring lead drug candidates to market quickly. In this article, we will discuss what is meant by drug metabolism and pharmacokinetics (DMPK) and explore its role in various stages of pharmaceutical development.
Developments in Agrigenomics content piece image

Developments in Agrigenomics

Agrigenomics is the application of modern genomics tools throughout agriculture. These tools offer food producers and researchers with insights that can increase productivity, reduce losses and improve sustainability.
A B cell, antibodies and a T cell, with CD8 and CD4 T cells illustrated.

Humoral vs Cell-Mediated Immunity

Humoral immunity and cell-mediated immunity are two types of an adaptive immune response that enable the human body to defend itself in a targeted way against harmful agents such as bacteria, viruses and toxins. Whilst there is some overlap between these arms of the immune response - both rely on the functions of lymphoid cells - there are also some important differences.